HIV Transmissions From a Window-Period Platelet Donation

Coagulation and Transfusion Medicine / HIV TRANSMISSION FROM PLATELET DONATION

Recently, blood centers began investigational testing for HIV RNA by pooled nucleic acid testing (NAT). A 35-year-old frequent platelet donor tested HIV p24 antigen positive, antibody negative before implementation of NAT. He made 2 platelet donations (day –4 and –11) immediately before testing positive for HIV. The donor’s HIV seroconversion was monitored, and stored samples were tested retros...

Consensus statement regarding the HIV "window period".

On 16 November, 1994, the combined National HIV Epidemiology and Laboratory Consensus Meeting (40 to 50 participants) considered the scientific evidence for defining the period of time following exposure and infection with HIV and the generation of detectable antibodies by the infected person, i.e., the so-called "window period". The following is the consensus statement that was reached followi...

Routine HIV screening among blood donors in Buenos Aires (Argentina): results from six years' experience and report of a single window-period donation.

BACKGROUND Blood donor HIV antibody detection has been mandatory in Argentina since 1991, and p24 antigen screening was recommended in 1997. METHODS A total of 30,132 consecutive donations were screened. Repeatedly reactive samples were tested by another screening test and/or by Western blot (WB) for HIV Ab, or by a neutralization assay for p24 Ag. RESULTS Among the total, 0.3623% of sample...

The HIV Seronegative Window Period: Diagnostic Challenges and Solutions

Platelet adhesiveness after blood donation.

Platelet adhesiveness to glass was measured in healthy blood donors at the time of and eight days after donating 500 ml of blood. By a whole blood method a highly significant increase was found whereas by a method using platelet-rich plasma with added adenosine diphosphate there was only a slightly significant increase. The discrepancy suggested that changes in the red cell population might inf...